Article

Interleukin-21 Drives a Hypermetabolic State and CD4 <sup>+</sup> T Cell-associated Pathogenicity in Chronic Intestinal Inflammation

2023-06-06

Abstract excerpt

<h4>BACKGROUND & AIMS</h4> Incapacitated regulatory T cells (Tregs) contribute to immune-mediated diseases. Inflammatory Tregs are evident during human inflammatory bowel disease (IBD); however, mechanisms driving the development of these cells and their function are not well understood. Therefore, we investigated the role of cellular metabolism in Tregs relevant to gut homeostasis. <h4>METHODS</h4> Using human...

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Literature Corpus work: 5cf62d4b-3c65-530a-baf9-bf153aad5cd2
DOI: 10.1101/2023.06.02.543518

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