Article

CTLA-4 inhibitors drive colitis through metabolic reprogramming-mediated Treg/Th17 imbalance

2026-01-21

Abstract excerpt

Immune checkpoint inhibitors (ICIs), especially CTLA-4 inhibitors (αCTLA-4), exhibit a high incidence of colitis as an immune-related adverse event (irAE) during cancer treatment, severely limiting patient benefit. Clinically, both treatment interruption and existing intervention drugs for ICI-mediated colitis may compromise antitumor efficacy. However, there is inadequate research on the pathogenesis of ICI-media...

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Literature Corpus work: 1f16aae2-0ade-536c-9efa-999a1a65f1c8
DOI: 10.64898/2026.01.20.700699

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