Article

The glycolytic reaction PGAM unexpectedly restrains Th17 pathogenicity and Th17-dependent autoimmunity

2024-08-19

Abstract excerpt

<h4>ABSTRACT</h4> Glucose metabolism is a critical regulator of T cell function, largely thought to support their activation and effector differentiation. Here, we investigate the relevance of individual glycolytic reactions in determining the pathogenicity of T helper 17 (Th17) cells using single-cell RNA-seq and Compass, an algorithm we previously developed for estimating metabolic flux from single-cell transcr...

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Literature Corpus work: 10f67475-1f44-56b9-8a3a-1aab03f57e53
DOI: 10.1101/2024.08.18.607992

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