Back to search

Article

ScRNA-seq Identified the Metabolic Reprogramming of Human Colonic Immune Cells in Different Locations and Disease States

2022-02-16

Abstract excerpt

<h4>ABSTRACT</h4> Different regions and states of the human colon are likely to have a distinct influence on immune cell functions. Here we studied the immunometabolic mechanisms for the spatial immune specialization and the dysregulated immune response during ulcerative colitis at single-cell resolution. We revealed that the macrophages and CD8 + T cells in the lamina propria (LP) of the human colon possessed a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ea267c0a-23f5-5368-9cf7-78e121c73427
DOI
10.1101/2022.02.14.480452
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
ScRNA-seq Identified the Metabolic Reprogramming of Human Colonic Immune Cells in Different Locations and Disease StatesDOI 10.1101/2022.02.14.480452
Single-cell transcriptome analysis reveals heterogeneity and convergence of the tumor microenvironment in colorectal cancerSemantic proximity
Understanding disease-associated metabolic changes in human colon epithelial cells using <i>i</i> ColonEpithelium metabolic reconstructionSemantic proximity
Spatiotemporal single cell transcriptomic analysis of human gut macrophages reveals multiple functional and niche-specific subsetsSemantic proximity
Integrated single-cell RNA-seq analysis identifies immune heterogeneity associated with KRAS/TP53 mutation status and tumor-sideness in colorectal cancers.Semantic proximity
Metabolic reprogramming and immunosenescence in colorectal cancer: mechanisms and therapeutic implicationsSemantic proximity
Ensemble-based genome-scale modeling predicts metabolic differences between macrophage subtypes in colorectal cancerSemantic proximity
Integrated multi-omics unveils novel immune signature for predicting prognosis in colon cancer patientsSemantic proximity
Metabolic Reprogramming of Pathogenic CD4 <sup>+</sup> T Helper Cells Attenuates Inflammatory Bowel Disease PathogenesisSemantic proximity
Metabolic features of innate lymphoid cellsSemantic proximity
TH17, TH22 and TReg Cells Are Enriched in the Healthy Human CecumSemantic proximity
An atlas of transcriptomic changes in human immune cells driven by 364 endogenous and gut-microbiota-derived metabolitesSemantic proximity
Inflammation-associated monocytes express ACOD1 to curtail inflammatory behaviour in IBD and experimental colitisSemantic proximity
Select a neighboring publication to make it the new centre.