Article

In Silico Modeling of Metabolic State in Single Th17 Cells Reveals Novel Regulators of Inflammation and Autoimmunity

2020-01-24

Abstract excerpt

<h4>ABSTRACT</h4> Cellular metabolism, a key regulator of immune responses, is difficult to study with current technologies in individual cells Here, we present Compass, an algorithm to characterize the metabolic state of cells based on single-cell RNA-Seq and flux balance analysis. We applied Compass to associate metabolic states with functional variability (pathogenic potential) amongst Th17 cells and recovered...

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Literature Corpus work: a59237cb-e671-5915-9d2d-e59e35b333e5
DOI: 10.1101/2020.01.23.912717

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