Article

TIGAR coordinates polyol and glutamine metabolism to regulate CD4+ T cells

2026-08-26

Abstract excerpt

<title>Abstract</title> <p>CD4⁺ T cells undergo extensive metabolic reprogramming during activation and differentiation, yet how metabolic enzymes coordinate metabolite utilisation with lineage commitment remains poorly understood. Here, we identify the metabolic enzyme TP53-induced glycolysis and apoptosis regulator (TIGAR) as a critical regulator of CD4⁺ T-cell fate. Although classically linked to glycolysis, T...

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Literature Corpus work: 7b0b609f-208f-5d1c-b4f1-1a50c876b52f
DOI: 10.21203/rs.3.rs-10438987/v1

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