Article

Glycolytic flux sustains human Th1 identity and effector function via STAT1 glycosylation

2025-02-08

Abstract excerpt

Fate decisions of T helper (Th) cells are tightly linked to their metabolic states, but precise mechanistic links remain unknown, especially in humans. Using in vitro stimulation in combination with gene editing we studied how metabolic regulation shapes human Th1 cell identity and effector function. Differentiated Th1 cells displayed elevated STAT1 phosphorylation at Tyr701 and Ser727 as well as heightened T-bet...

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Literature Corpus work: f4a7aac4-b164-5238-b3c9-93038974389f
DOI: 10.1101/2025.02.06.636644

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