Article

Leveraging Supramolecular Polymers to Induce the Targeted Protein Degradation of α-Synuclein

2026-07-23

Abstract excerpt

Halting the progression of neurodegenerative diseases remains one of the foremost challenges in medicinal chemistry due to the complex biology that drives disease progression. For example, a hallmark of synucleinopathies, such as Parkinson’s disease, is the misfolding and aggregation of the protein α-Synuclein (α-Syn), driving the formation of toxic oligomers and fibrils that avoid natural intracellular clearance...

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Literature Corpus work: b7af4b72-6092-57ba-855b-7cd06c046be6
DOI: 10.64898/2026.07.20.739556

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