Article
Modulating the Amyloidogenesis of α-Synuclein.
Current neuropharmacology - 1 Jan 2016
Sivanesam Kalkena, Andersen Niels H
Abstract excerpt
Alpha-Synuclein is found in the neuronal cells but its native function is not well known. While α -synuclein is an intrinsically disordered protein that adopts a helical conformation upon membrane binding, numerous studies have shown that oligomeric β-forms of this protein are cytotoxic. This response to misfolded species contributes to Parkinson's Disease etiology and symptoms. The resulting amyloid fibrils are...
Topics
- Amyloid
- Amyloidosis
- Animals
- Humans
- Mutation
- Parkinson Disease
- Protein Folding
- alpha-Synuclein