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Article

Modulating the Amyloidogenesis of α-Synuclein.

Current neuropharmacology - 1 Jan 2016

Sivanesam Kalkena, Andersen Niels H

Abstract excerpt

Alpha-Synuclein is found in the neuronal cells but its native function is not well known. While α -synuclein is an intrinsically disordered protein that adopts a helical conformation upon membrane binding, numerous studies have shown that oligomeric β-forms of this protein are cytotoxic. This response to misfolded species contributes to Parkinson's Disease etiology and symptoms. The resulting amyloid fibrils are...

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Identifiers

PMID: 26517049
DOI: 10.2174/1570159x13666151030103153
PMCID: PMC4857621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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