Article

Monoclonal antibodies targeting cytotoxic α-synuclein oligomers: molecular properties and diagnostic potential

2023-12-22

Abstract excerpt

<title>Abstract</title> <p>Aggregation of α-synuclein (α-syn) is critical to the development of synucleinopathies such as Parkinson’s Disease (PD), yet we do not have any effective therapy against these diseases. α-syn accumulates as insoluble amyloid in intracellular Lewy Bodies (LBs) but also forms soluble αSOs (αSOs) which are thought to be even more cytotoxic than fibrils. We lack tools to detect and block th...

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Literature Corpus work: 45f9a489-836f-57b0-a085-a40a1c5817d6
DOI: 10.21203/rs.3.rs-3778118/v1

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