Article

Direct disassembly of α-syn preformed fibrils into native α-syn monomers by an all-D-peptide

2023-12-11

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’s disease (PD) is the most common neurodegenerative movement disorder worldwide. One of its central features is the neurodegeneration that starts in the substantia nigra and progressively tends to involve other brain regions. α-Synuclein (α-syn) and its aggregation during pathogenesis have been drawn into the center of attention, where especially soluble oligomeric and fibrillar struct...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 938c8b97-8eba-55ba-83ee-0d788eb5f240
DOI: 10.1101/2023.12.11.571053

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Direct disassembly of α-syn preformed fibrils into native α-syn monomers by an all-D-peptideDOI 10.1101/2023.12.11.571053Read

Novel engineered nanobodies specific for N‐terminal region of alpha‐synuclein recognize Lewy‐body pathology and inhibit <i>in‐vitro</i> seeded aggregation and toxicitySemantic proximity Read

Inhibition of α-Synuclein Seeding-Dependent Aggregation by ssDNA Aptamers Specific to C-Terminally Truncated α-Synuclein FibrilsSemantic proximity Read

The good and bad of therapeutic strategies that directly target α‐synucleinSemantic proximity Read

Monoclonal antibodies targeting cytotoxic α-synuclein oligomers: molecular properties and diagnostic potentialSemantic proximity Read

Foldamers Reveal and Validate Novel Therapeutic Targets Associated with Toxic α-Synuclein Self-AssemblySemantic proximity Read

Molecular properties and diagnostic potential of monoclonal antibodies targeting cytotoxic α-synuclein oligomersSemantic proximity Read

Inhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model flies.Semantic proximity Read

Conformational Dynamics of α-Synuclein: A Study of its Intramolecular Forces in the Presence of Selected CompoundsSemantic proximity Read

A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitroSemantic proximity Read

Synergistic Multi-Pronged Interactions Mediate the Effective Inhibition of Alpha-Synuclein Aggregation by the Chaperone HtrA1Semantic proximity Read

Reduction of Alzheimer’s Disease Amyloid Plaque Load in Transgenic Mice by D3, a <scp>D</scp> ‐Enantiomeric Peptide Identified by Mirror Image Phage DisplaySemantic proximity Read

The aggregation of α-synuclein and its inhibtionSemantic proximity Read