Article

Programmable self-assembling system to model intracellular protein aggregation and decode neurodegenerative diseases

2025-03-10

Abstract excerpt

Pathological protein aggregation is a conserved feature of neurodegenerative diseases. However, slow progression, aggregates heterogeneity and selective vulnerability make it challenging to model diseases and dissect mechanisms. Here, we present a genetically-encoded, modular platform of self-assembling protein that enables inducible, tunable and cell-type-specific formation of intracellular protein aggregates. We...

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Literature Corpus work: c922e0ac-6f2f-57b4-9ba2-1a67dd5056ec
DOI: 10.1101/2025.03.06.641009

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