Article

Engineered Nanobodies With Programmable Target Antigen Proteolysis (Ptap) Fusions Regulate Intracellular Alpha-synuclein in Vitro and in Vivo

2024-03-28

Abstract excerpt

<title>Abstract</title> Alpha-synuclein (αSyn) aggregation and the formation of Lewy pathology (LP) is a foundational pathophysiological phenomenon in synucleinopathies. Delivering therapeutic single-chain and single-domain antibodies that bind pathogenic targets can disrupt intracellular aggregation. The fusion of antibody fragments to a negatively-charged proteasomal targeting motif (PEST) creates bifunction...

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Literature Corpus work: 8e25fc9e-6ced-5fb2-8f6f-7a6f9c64f717
DOI: 10.21203/rs.3.rs-4088206/v1

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