Article

Conformational Dynamics of α-Synuclein: A Study of its Intramolecular Forces in the Presence of Selected Compounds

2023-07-14

Abstract excerpt

Protein misfolding and aggregation play a role in amyloidogenic diseases through the self-assembly of intrinsically disordered proteins (IDPs) in type II diabetes (T2D), Alzheimer's (AD) and Parkinson's (PD) diseases. PD is the most common neurodegenerative disorder after AD, known for the loss of dopaminergic signaling, which causes motor and non-motor signs and symptoms. Lewy bodies and Lewy neurites are common...

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Literature Corpus work: c3690f97-a485-5b0d-b18c-31d746d91ae0
DOI: 10.21203/rs.3.rs-3137135/v1

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