Article

Chemoselective Semisynthesis of Covalent Nanobody-Guided Protein Degraders in Neurons

2026-03-10

Abstract excerpt

<title>Abstract</title> <p>The selective removal of pathological proteins represents a promising strategy for treating neurodegenerative diseases driven by protein aggregation and synaptic dysfunction. Here, we present a chemoselective semisynthesis platform that uses expressed protein ligation (EPL) to generate nanobody-guided degraders (nanodegraders, NDs) incorporating SuFEx (sulfur–fluoride exchange) covalent...

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Literature Corpus work: bf6258c2-908b-5dde-8457-b69fa3dafc17
DOI: 10.21203/rs.3.rs-8652640/v1

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