Article

Genetic Code Expansion, Enzymatic Modification, and C-Terminal Labeling Enable Facile Production of Highly Modified α-Synuclein

2026-06-25

Abstract excerpt

α-Synuclein (αS), a protein that plays a central role in Parkinson’s disease and related synucleinopathies, is an intrinsically disordered protein (IDP) whose functional interactions and aggregation behavior can be strongly influenced by post-translational modifications (PTMs). Phosphorylation, acetylation, and other PTMs regulate αS’s interactions with lipid membranes and binding partners, whereas their dysregula...

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Literature Corpus work: 633a100c-88e8-58bb-a8ee-2ed4b8e50a3c
DOI: 10.64898/2026.06.24.734353

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