Article

Targeted degradation of α-synuclein prevents PFF-induced aggregation

2025-04-19

Abstract excerpt

Accumulation of misfolded α-synuclein protein in intracellular inclusion bodies of dopaminergic neurons underlies the pathogenesis of Synucleinopathies, which include Parkinson’s Disease (PD), Dementia with Lewy Bodies (DLB) and Multiple System Atrophy (MSA). Therefore, clearance of misfolded α-synuclein from dopaminergic neurons could in principle offer a therapeutic window for Synucleinopathies, which currently...

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Literature Corpus work: 5d62a208-53ca-526d-b3ef-a18a419908d9
DOI: 10.1101/2025.04.15.648905

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