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Article

Foldamers rescue synucleinopathy phenotypes in multiple in vitro and in vivo models.

Science translational medicine - 1 Apr 2026

Dohoney Ryan A, Palanikumar L, Oldani Emily, Baysah Charles Zuwu, Joseph Johnson A, Polanco David, Santos-Otte Paula, Stillman Nicholas H, Corcoran Peter, Ball Tyler D, Fitch Tessa C, Ahmed Jemil, Ogbonna-Ukuku Ifunayachi, Reynolds Caicedo Kevin M, Liu Ying, Leehey Maureen A, Linseman Daniel A, Paredes Daniel A, Birol Melissa, Cremades Nunilo, Magzoub Mazin, Kumar Sunil

Abstract excerpt

Synucleinopathies is an umbrella term for multiple neurological disorders, including Parkinson's disease (PD), Lewy body dementia (LBD), and multiple system atrophy (MSA). A central pathological hallmark of synucleinopathies is the aggregation of α-synuclein (αS, a neuronal protein) and its prion-like spread. Therefore, inhibition of αS aggregation and spread is considered a viable therapeutic approach for the...

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Identifiers

PMID: 41920967
DOI: 10.1126/scitranslmed.adu1050
PMCID: PMC13430570

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