Article

Long-read sequencing reveals hidden structural complexity within Alzheimer's disease-associated GWAS loci

2026-03-17

Abstract excerpt

Genome-wide association studies (GWAS) typically represent Alzheimer's disease (AD) risk loci by a single lead SNP, although the lead SNP may capture only part of the genetic variation at a locus. We asked what genetic architectures underlie AD GWAS associations and how much information is obscured when a locus is reduced to a single lead SNP. We integrated AD GWAS summary statistics with long-read whole-genome se...

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Literature Corpus work: b68a4447-419c-50d6-9659-276711161254
DOI: 10.64898/2026.03.16.26348487

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