Article

Integration of Alzheimer’s disease genetics and myeloid genomics reveals novel disease risk mechanisms

2019-07-06

Abstract excerpt

Genome-wide association studies (GWAS) have identified more than thirty loci associated with Alzheimer’s disease (AD), but the causal variants, regulatory elements, genes and pathways remain largely unknown thus impeding a mechanistic understanding of AD pathogenesis. Previously, we showed that AD risk alleles are enriched in myeloid-specific epigenomic annotations. Here, we show that they are specifically enriche...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 450f3c54-836d-5b99-ada8-1c580c172c13
DOI: 10.1101/694281

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integration of Alzheimer’s disease genetics and myeloid genomics reveals novel disease risk mechanismsDOI 10.1101/694281Read

Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes.Semantic proximity Read

Genetics of the human microglia regulome refines Alzheimer’s disease risk lociSemantic proximity Read

Genetic risk for Alzheimer's disease is concentrated in specific macrophage and microglial transcriptional networks.Semantic proximity Read

Deep post-GWAS analysis identifies potential risk genes and risk variants for Alzheimer's disease, providing new insights into its disease mechanisms.Semantic proximity Read

Deep Post-GWAS Analysis Identifies Potential Risk Genes and Causal Variants for Alzheimer’s Disease, Providing New Insights Into Its Disease MechanismsSemantic proximity Read

Deep Post-GWAS Analysis Identifies Potential Risk Genes and Causal Variants for Alzheimer’s Disease, Providing New Insights Into Its Disease MechanismsSemantic proximity Read

Inferring the molecular mechanisms of noncoding Alzheimer’s disease-associated genetic variantsSemantic proximity Read

Alzheimer's disease risk genes and mechanisms of disease pathogenesis.Semantic proximity Read

Integrative genomic and transcriptomic analysis identifies microglia-expressed genes with causal links to Alzheimer's disease risk.Semantic proximity Read

Cell type-specific histone acetylation profiling of Alzheimer’s disease subjects and integration with geneticsSemantic proximity Read

Deciphering the functional impact of Alzheimer’s Disease-associated variants in resting and proinflammatory immune cellsSemantic proximity Read

Genomic partitioning of Alzheimer’s disease in humans reveals non-CNS etiologySemantic proximity Read