Article

Long-read genome sequencing and multi-omics in aging and neurodegeneration

2025-10-13

Abstract excerpt

Structural variants (SVs) are a major source of genetic variation yet remain underexplored in healthy aging and neurodegenerative diseases. We performed nanopore long-read genome sequencing (lrGS) on 551 deeply-phenotyped individuals from Stanfords Aging and Memory Study and Alzheimers Disease Research Center, generating a comprehensive SV map integrated with matched methylation, transcriptomic, and proteomic data...

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Literature Corpus work: 2a1fadae-a809-5450-83e7-0784b854637b
DOI: 10.1101/2025.10.10.25337775

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