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Article

Integrative genomics and single-cell CRISPRi screening dissect Alzheimer GWAS non-coding variants regulating TSPAN14.

American journal of human genetics - 4 Jun 2026

Laub Shannon, Tulina Natalia, Hoffman Matthew, Faryean Joe Bormeh, Ramachandran Sandhya, Trang Khanh, Lewkiewicz Stephanie M, Chesi Alessandra

Abstract excerpt

Genome-wide association studies (GWASs) have uncovered many associations for human complex diseases, but functional dissection of the discovered loci has lagged behind. We present a variant-to-gene (V2G) mapping effort for Alzheimer disease (AD) leveraging the most recent AD GWAS meta-analyses. In this study, we integrated ten brain-relevant genomics datasets-including promoter Capture C, ATAC-seq, and RNA-seq...

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Identifiers

PMID: 42190655
DOI: 10.1016/j.ajhg.2026.04.011
PMCID: PMC13240668

Genes

TSPAN14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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