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Article

Genetic risk for Alzheimer's disease is concentrated in specific macrophage and microglial transcriptional networks.

Genome medicine - 26 Feb 2018

Tansey Katherine E, Cameron Darren, Hill Matthew J

Abstract excerpt

BACKGROUND: Genome-wide association studies of Alzheimer's disease (AD) have identified a number of significant risk loci, the majority of which lie in non-coding regions of the genome. The lack of causal alleles and considerable polygenicity remains a significant barrier to translation into mechanistic understanding. This includes identifying causal variants and the cell/tissue types in which they operate. A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29482603
DOI: 10.1186/s13073-018-0523-8
PMCID: PMC5828245

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SPI1

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