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Article

Multi-ancestry transcriptome-wide association study reveals shared and population-specific genetic effects in Alzheimer disease.

American journal of human genetics - 4 Jun 2026

Sun Xinyu, Mews Makaela, Wheeler Nicholas R, Benchek Penelope, Gu Tianjie, Gomez Lissette, Ray Nicholas, Reitz Christiane, Naj Adam C, Below Jennifer Elizabeth, Tosto Giuseppe, Cornejo-Olivas Mario, Byrd Goldie S, Feliciano-Astacio Briseida E, Celis Katrina, Rajabli Farid, Kunkle Brian W, Pericak-Vance Margaret A, Haines Jonathan L, Griswold Anthony J, Bush William S

Abstract excerpt

Alzheimer disease (AD) risk differs across ancestral populations, yet most genetic studies have focused on non-Hispanic White (NHW) cohorts. We conducted a multi-population transcriptome-wide association study (TWAS) using whole-blood RNA sequencing (RNA-seq) and genotype data from NHW (n = 235), African American (AA; n = 224), and Hispanic (HISP; n = 292) Multi-Ancestry Genomics, Epigenomics, and Transcriptomics...

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Source

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Identifiers

PMID: 42066773
DOI: 10.1016/j.ajhg.2026.04.007
PMCID: PMC13247992

Genes

BIN1
COG4
DMPK
PIP
PTK2B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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