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Multi-ancestry Transcriptome-Wide Association Study Reveals Shared and Population-Specific Genetic Effects in Alzheimer’s Disease

2025-11-05

Abstract excerpt

Alzheimer’s disease (AD) risk differs across ancestral populations, yet most genetic studies have focused on non-Hispanic White (NHW) cohorts. We conducted a multi-population transcriptome-wide association study (TWAS) using whole-blood RNA-seq and genotype data from NHW (n=235), African American (AA; n=224), and Hispanic (HISP; n=292) MAGENTA participants. Using SuShiE for multi-population cis-eQTL fine-mapping,...

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Literature Corpus work
1ade8345-b6ae-5088-a994-ce4b6302c74d
DOI
10.1101/2025.11.03.686160
Open publication

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Multi-ancestry Transcriptome-Wide Association Study Reveals Shared and Population-Specific Genetic Effects in Alzheimer’s DiseaseDOI 10.1101/2025.11.03.686160
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