Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer's and Parkinson's diseases.

Nature genetics - 1 Nov 2020

Corces M Ryan, Shcherbina Anna, Kundu Soumya, Gloudemans Michael J, Frésard Laure, Granja Jeffrey M, Louie Bryan H, Eulalio Tiffany, Shams Shadi, Bagdatli S Tansu, Mumbach Maxwell R, Liu Boxiang, Montine Kathleen S, Greenleaf William J, Kundaje Anshul, Montgomery Stephen B, Chang Howard Y, Montine Thomas J

Abstract excerpt

Genome-wide association studies of neurological diseases have identified thousands of variants associated with disease phenotypes. However, most of these variants do not alter coding sequences, making it difficult to assign their function. Here, we present a multi-omic epigenetic atlas of the adult human brain through profiling of single-cell chromatin accessibility landscapes and three-dimensional chromatin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Variation, Population
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Epigenomics

Share to Genetic Heterogeneity

Share to Machine Learning

Share to Parkinson Disease

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 33106633
DOI: 10.1038/s41588-020-00721-x
PMCID: PMC7606627

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer's and Parkinson's diseases.PMID 33106633Read ↗

Single-cell epigenomic identification of inherited risk loci in Alzheimer’s and Parkinson’s diseaseSemantic proximity Read ↗

Modeling <i>cis</i> -regulatory variation in human brain enhancers across a large Parkinson’s Disease cohortSemantic proximity Read ↗

Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease allelesSemantic proximity Read ↗

Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles.Semantic proximity Read ↗

<i>MAPT</i> expression is mediated by long-range interactions with <i>cis</i> -regulatory elementsSemantic proximity Read ↗

Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia statesSemantic proximity Read ↗

Integrative Epigenomic Landscape of Alzheimer’s Disease Brains Reveals Oligodendrocyte Molecular Perturbations Associated with TauSemantic proximity Read ↗

Unraveling the complex role of MAPT-containing H1 and H2 haplotypes in neurodegenerative diseases.Semantic proximity Read ↗

Genetic regulation of cell type-specific chromatin accessibility shapes brain disease etiology.Semantic proximity Read ↗

Genetic regulation of cell-type specific chromatin accessibility shapes the etiology of brain diseasesSemantic proximity Read ↗

Advances in epigenetics and epigenomics for neurodegenerative diseases.Semantic proximity Read ↗

The three-dimensional landscape of chromatin accessibility in Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.