Article

Aberrant replication licensing drives Copy Number Gains across species

2020-10-10

Abstract excerpt

Copy Number Gains (CNGs) lead to genetic heterogeneity, driving evolution and carcinogenesis. The mechanisms promoting CNG formation however remain poorly characterized. We show that abnormal expression of the replication licensing factor Cdc18 in fission yeast, which leads to genome-wide re-replication, drives the formation of CNGs at different genomic loci, promoting the acquisition of new selectable traits. Who...

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Literature Corpus work: b5652c6f-698d-504e-b3a6-7250d5cbb1a4
DOI: 10.1101/2020.10.10.334516

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