Article

Transcription-Coupled Repair as a Mutagenic Mechanism During Replication Stress

2025-12-12

Abstract excerpt

Replication stress (RS) is a primary driver of genomic instability in cancer, yet the contribution of transcription-coupled repair to this process remains poorly understood. Here, we investigate how the TC-NER factor ERCC6 (CSB) shapes mutational landscapes under RS. We demonstrate that ERCC6 deficiency impairs replication restart and biases early damage signaling toward a 53BP1-mediated response, ultimately leadi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: df48c398-5a2e-524b-96f8-763e0daf82a3
DOI: 10.20944/preprints202512.1095.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcription-Coupled Repair as a Mutagenic Mechanism During Replication StressDOI 10.20944/preprints202512.1095.v1Read

Transcription-Coupled Repair Promotes the Retention of Mutations in Coding Regions During Replication Stress.Semantic proximity Read

DNA replication stress and cancer: cause or cure?Semantic proximity Read

Replicative Instability Drives Cancer ProgressionSemantic proximity Read

Quantifying replication stress in cancer without proliferation confoundingSemantic proximity Read

A p53-dependent FBXO44-RAD18 axis limits mutagenesis by terminating translesion DNA synthesisSemantic proximity Read

Error-prone bypass of DNA lesions during lagging strand replication is a common source of germline and cancer mutationsSemantic proximity Read

A universal molecular mechanism driving agingSemantic proximity Read

Aberrant replication licensing drives Copy Number Gains across speciesSemantic proximity Read

Identification of critical factors of the replication stress response in human cellsSemantic proximity Read

Clinical evidence for a role of E2F1-induced replication stress in modulating tumor mutational burden and immune microenvironment.Semantic proximity Read

Defective Replication Stress Response Is Inherently Linked to the Cancer Stem Cell Phenotype.Semantic proximity Read

Decoding Cancer Variants of Unknown Significance for Helicase–Nuclease–RPA Complexes Orchestrating DNA Repair During Transcription and ReplicationSemantic proximity Read