Article
Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer.
Nature cancer - 1 Dec 2024
Yang Yang, Badura Michelle L, O'Leary Patrick C, Delavan Henry M, Robinson Troy M, Egusa Emily A, Zhong Xiaoming, Swinderman Jason T, Li Haolong, Zhang Meng, Kim Minkyu, Ashworth Alan, Feng Felix Y, Chou Jonathan, Yang Lixing
Abstract excerpt
Despite the abundance of somatic structural variations (SVs) in cancer, the underlying molecular mechanisms of their formation remain unclear. In the present study, we used 6,193 whole-genome sequenced tumors to study the contributions of transcription and DNA replication collisions to genome instability. After deconvoluting robust SV signatures in three independent pan-cancer cohorts, we detected...
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