Article
Transcription-Coupled Repair Promotes the Retention of Mutations in Coding Regions During Replication Stress.
International journal of molecular sciences - 23 Jan 2026
Zambrano Evelyn, Fierro Cristopher, Morales Fernanda, Manterola Marcia, Marin Arnaldo, Armisen Ricardo, Marcelain Katherine
Abstract excerpt
Replication stress (RS) is a primary driver of genomic instability in cancer, yet the contribution of transcription-coupled repair (TC-NER) to this process remains unclear. Here, we investigate how the TC-NER factor ERCC6 (CSB) shapes mutational landscapes under RS. We found that ERCC6 deficiency biases early damage signaling toward a 53BP1-mediated response, ultimately leading to senescence. Conversely,...
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