Article

Systematic over-expression screens for chromosome instability identify conserved dosage chromosome instability genes in yeast and human tumors

2016-02-02

Abstract excerpt

Somatic copy number amplifications (SCNAs) and gene over-expression are common features of many cancers. To determine the role of gene over-expression on genome stability, we performed functional genomic screens in the budding yeast for chromosome instability, a defining characteristic of cancer that can be targeted by therapeutics. Over-expression of 245 yeast genes increases chromosome instability by influencing...

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Literature Corpus work: ee26b827-21d2-54cf-a1b3-0bf95a872651
DOI: 10.1101/038489

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