Article

The history of chromosomal instability in genome doubled tumors

2023-10-25

Abstract excerpt

Tumors frequently display high chromosomal instability (CIN) and contain multiple copies of genomic regions. Here, we describe GRITIC, a generic method for timing genomic gains leading to complex copy number states, using single-sample bulk whole-genome sequencing data. By applying GRITIC to 5,656 tumors, we found that non-parsimonious evolution is frequent in the formation of complex copy number states in genome-...

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Literature Corpus work: 2768b7d4-85b9-595b-a318-21d731a92668
DOI: 10.1101/2023.10.22.563273

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