Article

Whole genome doubling confers unique genetic vulnerabilities on tumor cells

2020-06-19

Abstract excerpt

<h4>Summary</h4> Whole genome doubling (WGD) occurs early in tumorigenesis and generates genetically unstable tetraploid cells that fuel tumor development. Cells that undergo WGD (WGD + ) must adapt to accommodate their abnormal tetraploid state; however, the nature of these adaptations, and whether they confer vulnerabilities that can subsequently be exploited therapeutically, is unclear. Using sequencing data...

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Literature Corpus work: 9aec66cc-648a-5cf6-9731-462f620e25be
DOI: 10.1101/2020.06.18.159095

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