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Large tandem duplications in cancer result from transcription and DNA replication collisions

2023-05-24

Abstract excerpt

Despite the abundance of somatic structural variations (SVs) in cancer, the underlying molecular mechanisms of their formation remain unclear. Here, we use 6,193 whole-genome sequenced tumors to study the contributions of transcription and DNA replication collisions to genome instability. After deconvoluting robust SV signatures in three independent pan-cancer cohorts, we detect transcription-dependent replicated-...

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Literature Corpus work
9c03fee8-a341-5da3-8e90-777ee35d841f
DOI
10.1101/2023.05.17.23290140
Open publication

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Large tandem duplications in cancer result from transcription and DNA replication collisionsDOI 10.1101/2023.05.17.23290140
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