Article

Replicative Instability Drives Cancer Progression

2022-05-06

Abstract excerpt

In the past decade, defective DNA repair has been increasingly linked with cancer progression. Human tumors with markers of defective DNA repair and increased replication stress have been shown to exhibit genomic instability and poor survival rates across tumor types. Here we utilize-omics data from two independent consortia to identify the genetic underpinnings of replication stress, therapy resistance, and prima...

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Literature Corpus work: 0198415d-e03c-529f-8ec7-7008ee08e61c
DOI: 10.1101/2022.05.06.490945

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