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Article

Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.

The Journal of biological chemistry - 12 Sept 2008

Hall Jonathan R, Lee Hyun O, Bunker Brandon D, Dorn Elizabeth S, Rogers Greg C, Duronio Robert J, Cook Jeanette Gowen

Abstract excerpt

The replication factors Cdt1 and Cdc6 are essential for origin licensing, a prerequisite for DNA replication initiation. Mechanisms to ensure that metazoan origins initiate once per cell cycle include degradation of Cdt1 during S phase and inhibition of Cdt1 by the geminin protein. Geminin depletion or overexpression of Cdt1 or Cdc6 in human cells causes rereplication, a form of endogenous DNA damage....

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Source

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Identifiers

PMID: 18617514
DOI: 10.1074/jbc.M802667200
PMCID: PMC2533066

Genes

DDB1
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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