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Article

Factors affecting the diversity of DNA replication licensing control in eukaryotes.

Current biology : CB - 24 Mar 2009

Drury Lucy S, Diffley John F X

Abstract excerpt

Replication of eukaryotic genomes is limited to once per cell cycle, by a two-step mechanism. DNA replication origins are first "licensed" during G1 phase by loading of an inactive DNA helicase (Mcm2-7) into pre-replicative complexes (pre-RCs). Initiation then occurs during S phase, triggered by...

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PMID: 19285403
DOI: 10.1016/j.cub.2009.02.034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19285403-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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