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Whole-genome doubling is a double-edged sword: the heterogeneous role of whole-genome doubling in various cancer types

14 Feb 2024

Abstract excerpt

Whole-genome doubling (WGD), characterized by the duplication of an entire set of chromosomes, is commonly observed in various tumors, occurring in approximately 30-40% of patients with different cancer types. The effect of WGD on tumorigenesis varies depending on the context, either promoting or suppressing tumor progression. Recent advances in genomic technologies and large-scale clinical investigations have...

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PMID: 38449300
DOI: 10.5483/bmbrep.2023-0244

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