Article

A global high-density chromatin interaction network reveals functional long-range and trans-chromosomal relationships

2022-03-27

Abstract excerpt

Chromatin contacts are essential for gene-expression regulation, however, obtaining a high-resolution genome-wide chromatin contact map is still prohibitively expensive owing to large genome sizes and the quadratic scale of pairwise data. Chromosome conformation capture (3C) based methods such as Hi-C have been extensively used to obtain chromatin contacts. However, since the sparsity of these maps increases with...

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Literature Corpus work: b41a4a37-8e04-5273-8a4c-2c3f75359676
DOI: 10.1101/2022.03.24.485503

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