Article

3DeFDR: Identifying cell type-specific looping interactions with empirical false discovery rate guided thresholding

2018-12-19

Abstract excerpt

The mammalian genome is connected into tens of thousands of long-range looping interactions critically linked to spatiotemporal gene expression regulation. An important unanswered question is to what extent looping interactions change across developmental models, genetic perturbations, drug treatments, and disease states. Although methods exist for calling loops in single biological conditions, there is a severe s...

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Literature Corpus work: 654c0c09-8070-5e05-8ed7-987d82390862
DOI: 10.1101/501056

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