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Article

Computational Identification of Genomic Features That Influence 3D Chromatin Domain Formation.

PLoS computational biology - 1 May 2016

Mourad Raphaël, Cuvier Olivier

Abstract excerpt

Recent advances in long-range Hi-C contact mapping have revealed the importance of the 3D structure of chromosomes in gene expression. A current challenge is to identify the key molecular drivers of this 3D structure. Several genomic features, such as architectural proteins and functional elements, were shown to be enriched at topological domain borders using classical enrichment tests. Here we propose multiple...

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Identifiers

PMID: 27203237
DOI: 10.1371/journal.pcbi.1004908
PMCID: PMC4874696

Genes

CTCF
ELK1
RXRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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