Article

Genome-wide absolute quantification of chromatin looping

2025-01-15

Abstract excerpt

3D genomics methods such as Hi-C and Micro-C have uncovered chromatin loops across the genome and linked these loops to gene regulation. However, these methods only measure 3D interaction probabilities on a relative scale. Here, we overcome this limitation by using live imaging data to calibrate Micro-C in mouse embryonic stem cells, thus obtaining absolute looping probabilities for 36,804 chromatin loops across t...

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Literature Corpus work: ae9f4e26-bbfe-5c76-b2b8-cdbee0fb0b80
DOI: 10.1101/2025.01.13.632736

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