Article

Deciphering Multi-way Interactions in the Human Genome

2021-08-15

Abstract excerpt

Chromatin architecture, a key regulator of gene expression, can be inferred using chromatin contact data from chromosome conformation capture, or Hi-C. However, classical Hi-C does not preserve multi-way contacts. Here we use long sequencing reads to map genome-wide multi-way contacts and investigate higher order chromatin organization in the human genome. We use hypergraph theory for data representation and analy...

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Literature Corpus work: eb0ed455-ff32-590d-8cd4-73935b130b8a
DOI: 10.1101/2021.08.15.456363

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