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Article

Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment.

Nature genetics - 1 Feb 2014

Hughes Jim R, Roberts Nigel, McGowan Simon, Hay Deborah, Giannoulatou Eleni, Lynch Magnus, De Gobbi Marco, Taylor Stephen, Gibbons Richard, Higgs Douglas R

Abstract excerpt

Gene expression during development and differentiation is regulated in a cell- and stage-specific manner by complex networks of intergenic and intragenic cis-regulatory elements whose numbers and representation in the genome far exceed those of structural genes. Using chromosome conformation capture, it is now possible to analyze in detail the interaction between enhancers, silencers, boundary elements and...

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PMID: 24413732
DOI: 10.1038/ng.2871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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