Article

A Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men

2021-04-27

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Several risk factors for coronary artery disease (CAD) have been described, some of which are genetically determined. The use of a polygenic risk score (PRS) could improve CAD risk assessment, but predictive accuracy according to age and sex is not well established. <h4>Methods</h4> A PRS CAD including the weighted effects of >1.14 million SNPs associated with CAD was calculat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b333549d-5d2d-5505-ab33-19d1b4552456
DOI: 10.1101/2021.04.25.21256083

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in MenDOI 10.1101/2021.04.25.21256083Read

Highly elevated polygenic risk scores are better predictors of myocardial infarction risk early in life than later.Semantic proximity Read

Polygenic risk score and coronary artery disease: A meta-analysis of 979,286 participant data.Semantic proximity Read

An integrated polygenic and clinical risk tool enhances coronary artery disease predictionSemantic proximity Read

Integrated Polygenic Tool Substantially Enhances Coronary Artery Disease Prediction.Semantic proximity Read

Taking the next steps to implement polygenic risk scoring for improved risk stratification and primary prevention of coronary artery disease.Semantic proximity Read

Polygenic risk scores in coronary artery disease.Semantic proximity Read

Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary preventionSemantic proximity Read

A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study.Semantic proximity Read

Predictive Accuracy of a Polygenic Risk Score-Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease.Semantic proximity Read

Incremental Value of Polygenic Risk Scores in Primary Prevention of Coronary Heart Disease: A Review.Semantic proximity Read

Polygenic score informed by genome-wide association studies of multiple ancestries and related traits improves risk prediction for coronary artery diseaseSemantic proximity Read

Polygenic Risk Scores: The Next Step for Improved Risk Stratification in Coronary Artery Disease?Semantic proximity Read