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Article

Taking the next steps to implement polygenic risk scoring for improved risk stratification and primary prevention of coronary artery disease.

European journal of preventive cardiology - 30 Mar 2022

Figtree Gemma Alexandra, Vernon Stephen Thomas, Nicholls Stephen James

Abstract excerpt

Coronary artery disease (CAD) remains the leading cause of death worldwide. The role of hypertension, cholesterol, diabetes mellitus, and smoking in driving disease has been well recognized at a population level and has been the target of primary prevention strategies for over 50 years with substantial impact. However, in many cases, these factors alone do not provide enough precision at the individual level to...

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PMID: 33624063
DOI: 10.1093/eurjpc/zwaa030

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