Article
A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study.
European heart journal - 7 May 2022
Lu Xiangfeng, Liu Zhongying, Cui Qingmei, Liu Fangchao, Li Jianxin, Niu Xiaoge, Shen Chong, Hu Dongsheng, Huang Keyong, Chen Jichun, Xing Xiaolong, Zhao Yingxin, Lu Fanghong, Liu Xiaoqing, Cao Jie, Chen Shufeng, Ma Hongxia, Yu Ling, Wu Xianping, Wu Xigui, Li Ying, Zhang Huan, Mo Xingbo, Zhao Liancheng, Huang Jianfeng, Wang Laiyuan, Wen Wanqing, Shu Xiao-Ou, Takeuchi Fumihiko, Koh Woon-Puay, Tai E Shyong, Cheng Ching-Yu, Wong Tien Yin, Chang Xuling, Chan Mark Yan-Yee, Gao Wei, Zheng Hong, Chen Kexin, Chen Jing, He Jiang, Tang Clara Sze-Man, Lam Karen Siu Ling, Tse Hung-Fat, Cheung Chloe Yu Yan, Takahashi Atsushi, Kubo Michiaki, Kato Norihiro, Terao Chikashi, Kamatani Yoichiro, Sham Pak Chung, Heng Chew-Kiat, Hu Zhibin, Chen Y Eugene, Wu Tangchun, Shen Hongbing, Willer Cristen J, Gu Dongfeng
Abstract excerpt
AIMS: To construct a polygenic risk score (PRS) for coronary artery disease (CAD) and comprehensively evaluate its potential in clinical utility for primary prevention in Chinese populations. METHODS AND RESULTS: Using meta-analytic approach and large genome-wide association results for CAD and CAD-related traits in East Asians, a PRS comprising 540 genetic variants was developed in a training set of 2800...
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