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Article

Predictive Accuracy of a Polygenic Risk Score-Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease.

JAMA - 18 Feb 2020

Elliott Joshua, Bodinier Barbara, Bond Tom A, Chadeau-Hyam Marc, Evangelou Evangelos, Moons Karel G M, Dehghan Abbas, Muller David C, Elliott Paul, Tzoulaki Ioanna

Abstract excerpt

Importance: The incremental value of polygenic risk scores in addition to well-established risk prediction models for coronary artery disease (CAD) is uncertain. Objective: To examine whether a polygenic risk score for CAD improves risk prediction beyond pooled cohort equations. Design, Setting, and Participants: Observational study of UK Biobank participants enrolled from 2006 to 2010. A case-control sample of...

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Identifiers

PMID: 32068818
DOI: 10.1001/jama.2019.22241
PMCID: PMC7042853

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