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Article

Polygenic risk score and coronary artery disease: A meta-analysis of 979,286 participant data.

Atherosclerosis - 1 Sept 2021

Agbaedeng Thomas A, Noubiap Jean Jacques, Mofo Mato Edith Pascale, Chew Derek P, Figtree Gemma A, Said M Abdullah, van der Harst Pim

Abstract excerpt

BACKGROUND AND AIMS: Coronary artery disease (CAD) is a complex disease with a strong genetic basis. While previous studies have combined common single-nucleotide polymorphisms (SNPs) into a polygenic risk score (PRS) to predict CAD risk, this association is poorly characterised. We performed a meta-analysis to estimate the effect of PRS on the risk of CAD. METHODS: Online databases were searched for studies...

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PMID: 34425527
DOI: 10.1016/j.atherosclerosis.2021.08.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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