Article

Polygenic score informed by genome-wide association studies of multiple ancestries and related traits improves risk prediction for coronary artery disease

2023-03-05

Abstract excerpt

Accurate stratification of coronary artery disease (CAD) risk remains a critical need. A new polygenic score (GPS Mult ) incorporates CAD genome-wide association data across five ancestries (>269,000 cases, >1,178,000 controls) with genetic association data for ten CAD risk factors. GPS Mult associates with an OR/SD 2.14, (95%CI:2.10-2.19,P<0.001) for prevalent CAD and HR/SD 1.73 (95%CI 1.70-1.76,P<0.001) for inci...

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Literature Corpus work: 3da4f5c1-63ec-547b-b04f-4702c3f9865f
DOI: 10.1101/2023.03.03.23286649

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